120 nm
spatial resolution
Micro Solutions / Life Science
CosMx Spatial Molecular Imager
Single-cell and subcellular spatial transcriptomics and proteomics: over 19,000 RNA targets
Product overview
- NanoString (Bruker Spatial Biology)
- USA
- CosMx SMI
- CosMx SMI
Single-cell and subcellular spatial transcriptomics and proteomics: over 19,000 RNA targets
For Research and Development Applications Only (RUO)
NanoString CosMx SMI from Bruker Spatial Biology is an integrated system of spatial transcriptomics and proteomics with single-cell and subcellular resolution to examine tissue without losing its architecture.
The platform uses cyclic fluorescent in situ hybridization and high-resolution imaging to localize RNA and proteins directly in FFPE and freshly frozen tissues, organoids and cell cultures. Segmentation algorithms define cell boundaries and assign individual transcripts to specific cells and intracellular regions. AtoMx Spatial Informatics Platform provides cloud storage, processing, visualization and analysis of research data.
CosMx SMI supports targeted panels of up to 6,000 RNA targets, full-transcriptom analysis of more than 19,000 RNA and simultaneous measurement of 64+ proteins. Spatial resolution is 120 nm, transcript localization accuracy is less than 50 nm; analyzes up to 3 million cells per slide, up to four slides per launch and up to 26 slides per week. The scan area reaches 300 mm² per slide. The system is designed for research applications only and is supplied as a complex of instrument, validated panels and reagents and AtoMx SIP platform.
Key figures
19 000+
target-RNA
3 million
glass-glass
RUO
research
Applications
- Spatial transcriptomics
- Spatial proteomics
- Oncological research
- Neurobiology
- Immunology
Models and configurations
- CosMx SMI
Product details
CosMx SMI
Integrated spatial visualization system
Comparison of CosMx panels
choice by density of multiplexing
Permission
- Cyclic fluorescent hybridization in situ
- Spatial resolution 120 nm, transcript localization accuracy less than 50 nm
- Cell segmentation and binding of transcripts to intracellular regions
Multiplexing
- Targeted RNA panels up to 6,000 targets
- Full-transcriptom analysis of more than 19,000 RNAs
- Simultaneous measurement of 64+ protein targets
Productivity and data
- Up to 3 million cells per slide, up to 4 slides per run, up to 26 slides per week
- Scanning area up to 300 mm2 per glass
- AtoMx Spatial Informatics Platform for Data Storage and Analysis
Visualization
| Method | cyclic fluorescent hybridization in situ |
|---|---|
| Spatial resolution | 120 nm |
| Accuracy of transcript localization | less than 50 nm |
Multiplexing
| RNA, targeted panels | up to 6,000 targets |
|---|---|
| RNA full of transcript | over 19,000 targets |
| Squirrel | 64+ targets simultaneously |
Throughput
| Cells on glass | 3 million |
|---|---|
| Launch slide | 4 |
| Slide a week | 26 |
| Scanning area | up to 300 mm2 in glass |
Platform
| Software | AtoMx Spatial Informatics Platform (Cloud) |
|---|---|
| Scope of application | Scientific Research Only (RUO) |
Panels and reagents
CosMx Human Whole Transcriptome Panel
Full-transcriptom RNA panel for CosMx SMI
Related equipment types
- GeoMx Digital Spatial Profiler
- nCounter Pro Analysis System
Classification
- Sequencing and genotyping
- Expression profiling and spatial biology
- Equipment for molecular biology and genetics
- Genotyping and Multiplex Platforms
- Platforms for Spatial Transcriptomics and Proteomics
- CosMx Spatial Molecular Imager