2-50 l
pilot-scale
Micro Solutions / Life Science
Bioreactors xCUBIO in-situ pilot and industrial scale
Stainless steel bioreactors for scaling from 2 l to more than 10,000 l
Product overview
- xCUBIO in-situ
- BBI-biotech
- Germany
- xCUBIO
- xCUBIO in-situ
Stainless steel bioreactors for scaling from 2 l to more than 10,000 l
SIP/CIP-compatible vessels with electropolished inner surface
The xCUBIO in-situ stainless steel bioreactors close the entire scaling path – from pilot plants with a capacity of 2–50 liters to production lines from 100 liters to more than 10,000 liters.
At the pilot level (2-50 l) the vessels are made of 316L steel (alternatively - 1.4435, 1.4571), with SIP sterilization of the vessel and sterile tracts and electric heating of the shirt; versions of hastelloy or fluoroplastic coating for aggressive media are available. At the production level (100 l - 10 000 + l), the line covers from individual vessels to complete production chains with SIP/CIP-compatible vessels and pipelines, sterile transfer of the seed culture to the main fermenter and coordinated valve automation.
The inner surface in contact with the product has a roughness Ra ≤0.8 μm (standard) or Ra ≤0.4 μm (option) and is electrically polished. Shaft sealing is double mechanical with condensate lubrication (standard for production scale); single seal or magnetic actuator is also available for pilot scale. calculated according to ASME, AD 2000 or other applicable requirements; it is provided for the connection of factory or pure steam or external steam generator. Each reactor is equipped with its own xCUBIO controller and touchpad 19′′ with graphical editors of sequences, valve logic and temporal profiles, OPC UA communication Production systems include FAT/SAT documentation sets and IQ/OQ templates.
Key figures
100 - 10,000+ l
production-scale
SIP/CIP
sterilization
Applications
- Scaling processes from pilot to production
- Microbial fermentation and cell culture
- Sterile production of biopharmaceutical products
- Precision Fermentation, Cell Agriculture
Models and configurations
- xCUBIO in-situ
Pilot scale (2–50 l)
- 316L steel vessels, alternatively 1.4435 or 1.4571
- SIP sterilization of the vessel and sterile tracts, electric heating of the shirt
- Also available are performances from hastelloy or with fluoroplastic coating for aggressive environments.
Production scale (100 l – 10 000+ l)
- From individual vessels to complete production lines
- SIP/CIP-compatible vessels and pipelines
- Sterile transfer of the seed culture to the main fermenter with coordinated valve automation
- A separate xCUBIO controller and a touchpad 19 for each reactor
Surface and sealing
- Internal surface roughness Ra ≤0.8 μm (standard) or Ra ≤0.4 μm (option), electropolishing
- Double mechanical sealing of the shaft with condensate lubrication; for the pilot scale also single seal or magnetic drive
Volume range
| Pilot scale | 2-50 l |
|---|---|
| Production scale | 100 l - 10,000+ l |
Materials and surface
| Vessel material | 316L/1.4404 stainless steel, optionally 1.4435, 1.4571, hastella |
|---|---|
| Roughness of the inner surface | Ra ≤0.8 μm (standard), Ra ≤0.4 μm (option) |
| Finishing | electropolish |
Automation
| Control panel | Touch screen 19′′ for each reactor |
|---|---|
| Connection | OPC UA, remote access over VNC, export of CSV |
Related equipment types
- Bioreactors and fermenters
- Bioprocess automation systems
- Sampling systems for bioreactors
Classification
- Biotechnology and bioprocesses
- Bioreactors and fermenters
- Equipment of cell technologies and reproductive medicine
- Cell incubation
- Bioreactors xCUBIO in-situ pilot and industrial scale