8
day-slide
Micro Solutions / Life Science
GeoMx Digital Spatial Profiler
Spatial profiling of RNA and proteins with a link to tissue morphology: up to 8 slides per day
Product overview
- NanoString (Bruker Spatial Biology)
- USA
- GeoMx DSP
- GeoMx DSP
Spatial profiling of RNA and proteins with a link to tissue morphology: up to 8 slides per day
UV-release of barcodes from selected areas and read on nCounter or NGS
NanoString GeoMx DSP from Bruker Spatial Biology is a system of spatial profiling of RNA and proteins that links molecular data to the morphology of preserved tissue and helps to investigate disease mechanisms in selected areas of the sample.
After morphological marker staining, GeoMx scans the drug, allows interactive selection of geometric, segmented, cell-specific or contour areas of interest, and releases photosensitive barcodes with ultraviolet light. The collected barcodes are analyzed on nCounter or NGS. The non-destructive approach supports FFPE and freshly frozen tissue, collaborative RNA and protein research and scaling from individual compartments to large cohorts.
GeoMx DSP processes up to 8 slides per day at 12 areas of interest on slide and scanning field 10 × 10 mm. Minimum UV irradiation area is 10 μm, optics is a 20 × / 0.45 NA lens, four fluorescent channels; four standard slide loads are simultaneously. Built-in storage is 8 TB. Dimensions - 76 × 73 × 61 cm, weight - 100 kg, 110-240 V, 50/60 Hz, 440 VA. RNA and protein are supported, up to 96 targets when reading nCounter and up to 20,000 targets for NGS.
Key figures
20 000
NGS targets
8 TB
storage
Applications
- Spatial transcriptomics
- Spatial proteomics
- Oncological research
- Immuno-oncology
Models and configurations
- GeoMx DSP
Product details
GeoMx DSP
tabletop
Workstation appliance
loading
Opportunities
- Selection of geometric, segmented, cell-specific and contour areas of interest
- UV release of photoactivated barcodes from a selected area without destroying the sample
- Joint analysis of RNA and protein in one slice
- Support for FFPE and freshly frozen fabrics
Throughput
- Up to 8 slide slides per day with 12 areas of interest on slide
- Scanning field 10 × 10 mm, minimum irradiation area 10 μm
- Simultaneous loading of four object slides
- Built-in data storage 8 TB
Optics and scanning
| Objective | 20x, numerical aperture 0.45 |
|---|---|
| Fluorescent channels | 4 |
| Minimum area of UV irradiation | 10 microns. |
| Scan field | 10 x 10 mm |
Throughput
| Capacity | Up to 8 slides/day (12 areas of interest per slide) |
|---|---|
| Simultaneous loading | 4 slide slides (1 x 3 inches) |
| Built-in storage | 8 TB (more than 300 images 10×10 mm, 4 channels) |
Multiplexing
| Reading on nCounter | up to 96 targets |
|---|---|
| NGS reading | up to 20,000 targets |
| Analysts | RNA and protein |
Dimensions and power supply
| Dimensions | 76 × 73 × 61 cm |
|---|---|
| Weight | 100 kg |
| Power supply | 110–240 V, 50/60 Hz, 440 VA |
Profiling panels
GeoMx Human Whole Transcriptome Atlas (WTA)
Full-transcriptom RNA panel for spatial profiling of human tissues
Related equipment types
- nCounter Pro Analysis System
- CosMx Spatial Molecular Imager
- Histological slide scanners
Related products
- Yokogawa CSU-W1 — Histological slide scanners
Classification
- Sequencing and genotyping
- Expression profiling and spatial biology
- Equipment for molecular biology and genetics
- Genotyping and Multiplex Platforms
- Platforms for Spatial Transcriptomics and Proteomics
- GeoMx Digital Spatial Profiler