ASI HiFISH
compatibility
Micro Solutions / Life Science
FISH ZytoLight probes for oncohematology and prenatal diagnosis
ZytoLight SPEC probes for hematology, solid tumors and prenatal panels
Product overview
- FISH probes
- ZytoVision
- Germany
ZytoLight SPEC probes for hematology, solid tumors and prenatal panels
Directly labeled probes compatible with ASI HiFISH digital FISH analysis systems
ZytoLight SPEC probes cover key panels of oncohematology, solid tumors and prenatal diagnostics and are compatible with ASI HiFISH digital FISH analysis systems.
For oncohematology, the range includes dual-fusion probes (BCR/ABL1, ETV6/RUNX1, PML/RARA), break-apart probes (MYC, BCL2, BCL6, IGH, KMT2A), and immunoglobulin-locus probes. Solid-tumor probes cover amplification (ERBB2/CEN 17, EGFR/CEN 7, MET/CEN 7), translocations (ALK, ROS1, NTRK1/2/3, EML4), and deletions (TP53/CEN 17, PTEN/CEN 10, VHL/CEN 3). Prenatal and constitutional panels cover aneuploidies 13/18/21/X/Y and the DiGeorge, Williams–Beuren, Prader–Willi and Angelman microdeletion syndromes.
The probes carry a direct fluorescent tag and come in Dual Fusion, Break Apart and Enumeration formats. The manufacturer confirms the high compatibility of ZytoVision probes with Applied Spectral Imaging (ASI) systems for the HiFISH platform, a digital FISH analysis with an automated workflow, including examples of ERBB2 amplification analysis, Reconstructions of EWSR1 and fusion COL1A1-PDGFB. CE-IVD products are labeled according to IVDR (EU) 2017/746.
Key figures
CE-IVD
IVDR marking
Applications
- Hematological translocations
- Amplifications and deletions of solid tumors
- Aneuploidy 13/18/21/X/Y
- Microdeletion syndromes
Models and configurations
- Oncohematology
- Solid tumors.
- Prenatal and constitutional diagnosis
Oncohematology
- Dual fusion probes BCR/ABL1, ETV6/RUNX1, PML/RARA
- Break-apart probes MYC, BCL2, BCL6, IGH, KMT2A
- Probes of immunoglobulin loci IGH, IGK, IGL
Solid tumors.
- Amplification of ERBB2/CEN 17, EGFR/CEN 7, MET/CEN 7
- Translocations ALK, ROS1, NTRK1/2/3, EML4
- Deletions TP53/CEN 17, PTEN/CEN 10, VHL/CEN 3
Prenatal and constitutional diagnosis
- Aneuploidy panels 13/18/21/X/Y
- Microdeletion syndrome probes DiGeorge, Williams-Beuren, Prader-Willi, Angelman
Technology and application
| Probe format | Fishes: Dual Fusion, Break Apart, Enumeration |
|---|---|
| Compatibility with visualization | Tested on ASI (HiFISH) systems for automated digital FISH analysis |
| Registry | CE-IVD by IVDR (EU) 2017/746 |
Model range
| Oncohematology | BCR/ABL1, ETV6/RUNX1, PML/RARA, MYC, BCL2, BCL6, IGH, KMT2A, IGK, IGL |
|---|---|
| Solid tumors. | ERBB2/CEN 17, EGFR/CEN 7, MET/CEN 7, ALK, ROS1, NTRK1/2/3, EML4, TP53/CEN 17, PTEN/CEN 10, VHL/CEN 3 |
| Prenatal diagnosis | panels 13/18/21/X/Y; microdeletions DiGeorge, Williams-Beuren, Prader-Willi, Angelman |
Related equipment types
- FISH (ASI HiFISH) Visualization Systems
- Hybridization stations
- Fluorescent microscopes
Related products
- Berthold NightSHADE LB 985 — FISH (ASI HiFISH) Visualization Systems
- Jeio Tech hybridization furnace — Hybridization stations
- Ningbo Sunny Instruments EX30 — Fluorescent microscopes
Classification
- Consumables
- FISH probes
- cytogenetic equipment
- Reagents for cytogenetics
- FISH probes (oncohematology, solid tumors, prenatal)
- FISH probes