<4 min
amino acid cycle
Micro Solutions / Life Science
Peptide Synthesizer Liberty PRIME 2.0
High-performance microwave synthesis of peptides: up to 24 synthesises in line
Product overview
- Liberty PRIME 2.0
- CEM
- USA
- Liberty 2.0
- Liberty PRIME 2.0
High-performance microwave synthesis of peptides: up to 24 synthesises in line
solid-phase synthesis with five-channel reagent supply and cGMP option
Liberty PRIME 2.0 is a high-performance microwave peptide synthesis platform for laboratories that need high load, reagent savings and scaling from research to production tasks.
The platform automatically performs dosing, combination, deblocking, stirring and draining using microwave control and direct fiber-optic temperature measurement. The five-channel pump system speeds up the delivery of reagents, and No-Wash and UE-SPPS reduce the volume of washes. The HT4, HT12 and HT24 modules allow you to queue up to 24. independent synthesis; cGMP package is available for controlled processes.
Scale range: 0.005-5 mmol: The full amino acid addition cycle takes less than 4 minutes, waste consumption less than 5 ml per addition under standard conditions specified by the manufacturer. Configuration includes 30 amino acid positions, a five-channel pump, a microwave reaction chamber and fiber-optic temperature control. The software supports the requirements of 21 CFR Part 11; cGMP-compatible configuration is available. The final performance depends on the sequence and protocol.
Key figures
30
amino acid positions
HT24
max.line of synthesis
cGMP
optional
Applications
- Peptide synthesis
- Antigens and epitopes
- Peptide factors for cell cultures
- High-performance solid-phase synthesis
Models and configurations
- Liberty PRIME 2.0
Product details
Liberty PRIME 2.0 with HT24
queue of up to 24 syntheses
High-performance supply of reagents
synthesis-line
Throughput
- Complete cycle of attachment and deblocking of one amino acid - less than 4 minutes at a scale of 0.1 mmol
- Waste – less than 5 ml per amino acid under standard conditions
- Five-channel pump system accelerates the supply of reagents
Flexibility
- Synthesis scale - from 0.005 to 5 mmol
- 30 positions for amino acids, up to 5 external reagent positions
- No-Wash and UE-SPPS reduce washing volume
Scaling and regulation
- HT4, HT12 and HT24 modules allow up to 24 independent synthesises to be queued up.
- Available optional package of full compliance with cGMP
- Supports the requirements of 21 CFR Part 11
Synthesis
| Scope | 0.005-5 mmol |
|---|---|
| Cycle time (at 0.1 mmol) | < 4 min per amino acid |
| Waste (at 0.1 mmol) | < 5 ml per amino acid |
| Amino acid positions | 30 |
| External reagent positions | up to 5 (2 activators, deblocking, washing, additional position) |
Equipment
| Pumping system | five-channel |
|---|---|
| Reaction vessel chamber | Yes |
| LED status indication | Yes |
| Purging headspace | Yes |
| High-performance options | HT4, HT12, HT24 |
Software and regulatory
| Compatibility of SOEs | 21 CFR Part 11 |
|---|---|
| Optional package | full compliance with cGMP |
High-performance modules
HT4
Quest for up to 4 independent synthesises
HT12
Quest for up to 12 independent synthesises
HT24
Quest for up to 24 independent synthesises
Regulatory packages
Full cGMP Compliance Package
Components for controlled synthesis processes
Related equipment types
- Preparative HPLC for peptide cleaning
- Lyophile dryers
- Production-scale solid-phase synthesis systems
Related products
- BUCHI Lyovapor L-210 — Lyophile dryers
- Anpel vacuum manifold — Production-scale solid-phase synthesis systems
Classification
- Cellular technology and ART
- Scientific and production equipment
- Peptide synthesizers
- Peptide synthesis
- Equipment for molecular biology and genetics
- Nucleic acid and peptide synthesis
- Peptide synthesizers
- Liberty PRIME 2.0