<4 min
amino acid cycle
Micro Solutions / Life Science
Synthesizer peptides Liberty Blue 2.0
Microwave synthesis of peptides: less than 4 minutes for the addition of an amino acid
Product overview
- Liberty Blue 2.0
- CEM
- USA
- Liberty 2.0
- Liberty Blue 2.0
Microwave synthesis of peptides: less than 4 minutes for the addition of an amino acid
solid-phase synthesis with expansion to 12 parallel runs (HT12 module)
Liberty Blue 2.0 is an automatic microwave peptide synthesizer for rapid development and routine solid-phase synthesis: a typical attachment of a single amino acid along with deblocking takes less than four minutes.
The system automates reagent dosing, microwave acceleration of combination and deblocking, mixing and draining. No-Wash and UE-SPPS technologies reduce the number of washes and solvent consumption, and a fiber optic sensor monitors the temperature directly in the reaction vessel. The basic configuration can be supplemented with HT4 modules. or HT12 for queuing up to four or twelve synthesises, respectively.
Synthesis scale range - 0.005-5 mmol. The full cycle of amino acid addition - less than 4 minutes at a scale of 0.5 mmol; waste consumption - less than 6 ml per addition at a scale of up to 0.2 mmol. 27 amino acid positions and 2 activator positions are provided, microwave heating with direct fiber-optic temperature measurement and software supporting 21 CFR Part 11 requirements. Actual performance depends on the sequence, resin and the protocol selected.
Key figures
27
amino acid positions
HT4 / HT12
synth-queue options
21 CFR 11
software compatibility
Applications
- Peptide synthesis
- Antigens and epitopes
- Peptide factors for cell cultures
- Solid-phase synthesis (SPPS)
Models and configurations
- Liberty Blue 2.0
Product details
Liberty Blue 2.0 with HT12 module
queue of up to 12 syntheses
Working with peptide resin
UE-SPPS technology
Speed and economy
- Complete cycle of attachment and deblocking of one amino acid - less than 4 minutes at a scale of 0.1 mmol
- No-Wash and UE-SPPS technologies reduce washing and solvent consumption – less than 6 ml of waste per amino acid
- A fiber-optic sensor monitors the temperature directly in the reaction vessel
Flexibility
- Synthesis scale - from 0.005 to 5 mmol
- 27 amino acid and 2 activator positions, up to 4 external reagent positions
- Reaction vessel camera and LED process indication
Scaling
- HT4 and HT12 modules allow up to 4 or 12 independent synthesises to be queued.
- Supports the requirements of 21 CFR Part 11
Synthesis
| Scope | 0.005-5 mmol |
|---|---|
| Cycle time (at 0.1 mmol) | < 4 min per amino acid |
| Waste (at 0.1 mmol) | < 6 ml per amino acid |
| Amino acid positions | 27 |
| External reagent positions | 4 (2 activators, deblocking, washing) |
Equipment
| Reaction vessel chamber | Yes |
|---|---|
| LED status indication | Yes |
| Purging headspace | Yes |
| High-performance options | HT4, HT12 |
Software
| Compatibility | 21 CFR Part 11 |
|---|
High-performance modules
HT4
queue of up to 4 independent synthesises without operator involvement
HT12
Up to 12 independent synthesises without operator
Related equipment types
- Preparative HPLC for peptide cleaning
- Lyophile dryers
- Production-scale solid-phase synthesis systems
Related products
- BUCHI Lyovapor L-210 — Lyophile dryers
- Anpel vacuum manifold — Production-scale solid-phase synthesis systems
Classification
- Cellular technology and ART
- Scientific and production equipment
- Peptide synthesizers
- Peptide synthesis
- Equipment for molecular biology and genetics
- Nucleic acid and peptide synthesis
- Peptide synthesizers
- Liberty Blue 2.0