>50 000
FSR (impact II) resolution
Micro Solutions / Life Science
Toxicological Screening Solution for ToxScreener
Screening of hundreds of known and new psychoactive substances by exact mass with retrospective search
Product overview
- ToxScreener
- Bruker
- USA
- ToxScreener on qTOF
- ToxScreener
Screening of hundreds of known and new psychoactive substances by exact mass with retrospective search
UHPLC-QTOF with bbCID fragmentation and exact mass base of toxicologically significant substances
A comprehensive UHR-QTOF solution for forensic toxicology screening of known and emerging psychoactive substances.
ToxScreener combines UHPLC, full-scanning precision measurement and bbCID fragmentation with a database of forensic toxicological compounds. The complete dataset allows for validation and retrospective search of compounds without remeasuring the sample.
The solution uses precise precursor and fragment masses, isotopic profile, retention time and qualifier ions. Compatible QTOF impact II systems provide a resolution of more than 50,000 at full sensitivity, a five-order dynamic range and a spectra collection rate of up to 50 Hz.
Key figures
50 Hz
spectra-collection
5 orders of magnitude
range
bbCID
fragmentation
Applications
- Forensic toxicology
- New psychoactive substances
- Postmortem samples
- Seized drugs
- Data retrospective analysis
Models and configurations
- ToxScreener on impact II
Product details
QTOF-based impact II VIP platform
precise mass and wide dynamic range
Completeness of data
- Full-scanned precision mass measurement together with bbCID broadband fragmentation
- Allows you to check hundreds and thousands of known and previously unknown compounds
- The stored data is available for retrospective search without reanalyzing the sample
Reliable identification
- Exact masses of molecular ions, adducts, isotopes and diagnostic fragments
- Reduce false positives even in complex matrices, including postmortem samples
- Precision base of substances of forensic and toxicological significance
Platform performance
- Resolution of over 50,000 with full sensitivity
- Dynamic range of 5 orders of magnitude at UHPLC speeds
- Spectrum collection speed up to 50 Hz
Workflow
| Method | UHPLC-QTOF: full scan of MS + bbCID |
|---|---|
| Identification criteria | Precise mass of precursor and fragments, isotopic profile, retention time, qualifier ions |
| Database | Precision base of substances of forensic and toxicological significance |
Mass spectrometer (impact II)
| Full resolution at full sensitivity | >50 000 |
|---|---|
| Dynamic range | 5 orders of magnitude |
| Speed of spectra collection | up to 50 Hz |
Software
TargetScreener HR / TASQ
Screening, quantitative analysis and reporting; database of more than 3,000 compounds
MetaboScape
Search for unexpected connections and identify “known unknowns”
Libraries
NIST DART-MS Forensics Database (2021)
Libraries for judicial tasks
Maurer/Meyer/Helfer/Weber: LC-HR-MS/MS Library of Drugs, Poisons, and Their Metabolites
Library of Spectra of Drugs, Poisons and Metabolites
Related equipment types
- HPLC/UHPLC systems
- Nitrogen generators
- Centrifuges
- Sample-preparation systems (SPE)
Related products
- Cence TG16-WS — Centrifuges
Classification
- Toxicology and omics
- Screening of narcotic and psychoactive substances
- Analytical instruments for biological samples
- Mass spectrometry
- Q-TOF and ionic mobility (timsTOF): proteomics, metabolomics
- ToxScreener