3 holes/s
reading-point
Micro Solutions / Life Science
TIMSTOF MALDI PharmaPulse
TIMS-MALDI ultra-high-throughput screening solution – up to 1 million compounds
Product overview
- timsTOF MALDI PharmaPulse
- Bruker
- Germany
- timsTOF
- timsTOF MALDI PharmaPulse
TIMS-MALDI ultra-high-throughput screening solution – up to 1 million compounds
Read speeds up to 3 holes/s and QTOF resolution of 50,000
TIMS-MALDI is a solution for high- and ultra-high-performance screening.
The platform reads biochemical and cellular analyses by exact mass, separates isobars and isomers by TIMS, and integrates with laboratory automation, supporting quantitative tests, affinity-selection MS, and control of synthesis products.
Reading speeds reach 3 holes/s; microplate 1536 format is analyzed in less than 10 minutes. Used QTOF with a typical resolution of 50,000, 10 kHz smartbeam 3D, dual MALDI/ESI and optional MALDI-2.
Key figures
1536
microplate
50 000
QTOF
10 kHz
Smartbeam 3D laser
Applications
- High-performance screening (HTS/uHTS)
- Enzymatic analyses
- Affinity-selection MS
- Control of chemical synthesis products
- High-throughput experimentation (HTE)
Models and configurations
- timsTOF MALDI PharmaPulse
Product details
timsTOF MALDI PharmaPulse
Platform for ultra-high-performance screening
Analysis software
Screening data processing
Throughput
- The 1536 hole microplate is read in less than 10 minutes at speeds up to 3 holes / s.
- Primary screenings cover more than 1 million compounds
- 10 kHz smartbeam 3D laser provides maximum system availability
precision
- QTOF analyzer gives a typical resolution of 50,000
- TIMS separates isobaric and isomeric compounds before MS/MS
Source flexibility
- ESI/MALDI dual source without complex reconfiguration
- Optional MALDI-2 post-ionization expands the chemical space
Screening
| Reading speed | up to 3 holes/s |
|---|---|
| Microplate format | 1536 holes (less than 10 minutes per microplate) |
| Capacity of primary screening | more than 1 million compounds |
Mass spectrometer
| Type | TIMS-QTOF with dual source ESI/MALDI |
|---|---|
| Permission (typical) | 50 000 |
| laser | smartbeam 3D, 10kHz |
| MALDI-2 | optionally |
Related equipment types
- Liquid dosing systems
- Laboratory automation
- Screening software
Related products
- Volab V9 Series — Laboratory automation
Classification
- Toxicology and omics
- Proteomics
- Analytical instruments for biological samples
- Mass spectrometry
- Q-TOF and ionic mobility (timsTOF): proteomics, metabolomics
- TIMSTOF MALDI PharmaPulse