Bruker
EVOQ LC-TQ Neonatal Screening System with RECIPE Sets
Amino acids and acylcarnitines from dry blood spot for 1.0-1.5 minutes per sample
A bundle of triple quadrupole EVOQ LC-TQ and RECIPE sets for LC-MS / MS screening of newborns: amino acids and acylcarnitines from dry blood spot for 1.0-1.5 minutes.
Request a quotationThe solution combines EVOQ’s desktop mass spectrometer, RECIPE ClinMass chromatography and ready-made kits with reagents, calibrators and controls, and is designed to simultaneously profile markers of inherited metabolic disorders in DBS, and the panel is expanded with homocysteine kits.
The set for derivatized amino acids and acylcarnitines covers 13 amino acids, free carnitine and acylcarnitines C2-C18; the technique corresponds to CLSI NBS-04A, the analysis time is 1.0-1.5 minutes Mass spectrometer EVOQ operates in MRM mode with scanning speed up to 14,000 AU / s and polarity change in 25 ms.
Screening from DBS
- Simultaneous determination of 13 amino acids, carnitine and acylcarnitines C2–C18 from a dry blood spot
- The method is in accordance with CLSI NBS-04A
- Analysis time of 1.0–1.5 min per sample
Dashboard.
- Triple quadrupole EVOQ: scanning up to 14,000 AU/s, polarity change in 25 ms
- VIP-HESI source carefully ionizes thermolabile compounds
- PACER with exception checks
Expansion of the panel
- ClinMass kits for total homocysteine with an injection interval of 1.0 min
- Separate ClinCal calibrators and ClinCheck controls for amino acids
Analytical panel
| Parameter | EVOQ LC-TQ + RECIPE ClinMass |
|---|---|
| Matrix | Dry blood spots (DBS) |
| Amino acids | 13: alanine, arginine, aspartic acid, citrulline, glutamic acid, glycine, leucine, methionine, ornithine, phenylalanine, proline, tyrosine, valine |
| Acylcarnitine | Free carnitine, C2–C18, including hydroxy, dicarboxylic and unsaturated forms |
| Sample preparation | With derivatization |
| Time for analysis | 1.0–1.5 minutes |
Mass spectrometer
| Parameter | EVOQ LC-TQ + RECIPE ClinMass |
|---|---|
| Type | Triple quadrupole EVOQ LC-TQ, MRM mode |
| Scan speed | up to 14,000 AU/s |
| Polar switching | 25ms |
| Sources of ionization | VIP-HESI, APCI |