LC-MS/MS
kit-format
Micro Solutions / Life Science
ClinMass kits for LC-MS/MS clinical trials
Ready-made LC-MS/MS kits for small molecules: from amino acids to 11 antifungal drugs
Product overview
- Assay Kits for Clinical Research
- RECIPE
- Germany
- EVOQ is a triple quadrupole
- Assay Kits for Clinical Research
Ready-made LC-MS/MS kits for small molecules: from amino acids to 11 antifungal drugs
RECIPE kits in Bruker's Triple Quadrupoles EVOQ portfolio
Ready-made RECIPE ClinMass kits translate LC-MS/MS-detection of small molecules into a standardized routine process: from amino acids in dry blood spots to therapeutic drug monitoring.
Each set includes consistent reagents, calibrators, controls and techniques for a specific group of analytes and matrix. The portfolio includes screening of amino acids and acylcarnitines in DBS, determination of total homocysteine and methylmalonic acid, and a ClinMass TDM modular system with additional sets for drug classes.
For amino acids and acylcarnitines in DBS, the technique corresponds to CLSI NBS-04A, the analysis time is 1.0-1.5 minutes; for homocysteine, the injection interval is 1.0 minutes. The ClinMass MS9600 set on the MS9000 platform quantifies 11 antifungal drugs in serum and plasma with an inter-series precision of 1.8-13.4 %. It's sensitive enough.
Key figures
1.0 minutes
interval of injection (homocysteine)
11
Antimycotics in one method
DBS
blood-stain
Applications
- Neonatal screening
- Hereditary exchange diseases
- Therapeutic drug monitoring
- Definition of homocysteine
- Methylmalonic acid
Models and configurations
- Amino acids and acylcarnitines (DBS)
- homocysteine
- Methylmalonic acid
- TDM: Antifungal drugs
Product details
ClinMass kits
Reagents, calibrators and controls in one set
Workflow completed
- Complete kits standardize sample preparation and LC-MS/MS measurement
- Single-stage sample preparation for methylmalonic acid, simple and fast - for homocysteine
- The method for amino acids and acylcarnitines in DBS is in accordance with CLSI NBS-04A
Modularity
- ClinMass TDM system is built on the universal MS9000 platform with additional sets for groups of drugs
- MS9600 Set identifies 11 serum and plasma antifungal drugs
- The portfolio is regularly supplemented with new classes of drugs
Quality control
- Separate ClinCal calibrators and ClinCheck controls for plasma amino acids
- Specific separation of methylmalonic acid and isobaric succinic acid
Samples and analytes
| Matrix | Dry blood stains Plasma, serum, DBS Plasma, serum, urine. Serum, plasma. |
|---|---|
| Analysts | 13 amino acids (alanine, arginine, aspartic acid, citrulline, glutamic acid, glycine, leucine, methionine, ornithine, phenylalanine, proline, tyrosine, valine), carnitine and acylcarnitines C2–C18 Common homocysteine Methylmalonic acid 5-fluorocytosine, amphotericin B, anidulafungin, fluconazole, isauuconazole, itraconazole, hydroxytraconazole, ketoconazole, mykafungin, poraconazole |
Methodology.
| Analysis time/injection interval | 1.0–1.5 minutes 1.0 minutes — — |
|---|---|
| Sample preparation | Derivatization Simple and fast. Single-stage — |
| Features | CLSI NBS-04A Methodology — Separation with isobaric succinic acid MS9000 + MS9600 set; ClinCal Serum MS9613 calibrator |
Precision (TDM antifungal)
| Inter-Series Precision | — — — 1.8–13.4% (2 levels, 8 days) |
|---|
Compatibility
| Equipment | LC-MS/MS (triple quadrupole) with sufficient sensitivity, including EVOQ with VIP-HESI source |
|---|
Related equipment types
- Triple quadrupole LC-MS/MS systems
- HPLC/UHPLC systems
- Centrifuges
- Metering stations and sample preparation stations
Related products
- Cence TG16-WS — Centrifuges
- AHN Biotechnologie CAPP Bravo — Metering stations and sample preparation stations
Classification
- Toxicology and omics
- Hormones, Vitamins and Drug Monitoring
- Analytical instruments for biological samples
- Ready-made analytical kits for HPLC and MS
- ClinMass kits for LC-MS/MS clinical trials