Micro Solutions / Life Science

Desktop bioreactors xCUBIO single / xCUBIO twin

Table bioreactors xCUBIO: one or two vessels with a volume of 250 ml to 10 l

Product overview

xCUBIO single / xCUBIO twin
BBI-biotech
Germany
xCUBIO
xCUBIO single / xCUBIO twin

Table bioreactors xCUBIO: one or two vessels with a volume of 250 ml to 10 l

glass and autoclaved vessels, automation on the xCUBIO platform

Desktop bioreactors xCUBIO single and xCUBIO twin - one or two independent vessels with a volume of 250 ml to 10 liters with a full set of control and measuring instruments and automation on the xCUBIO platform.

xCUBIO single is a single-vessel bioreactor, xCUBIO twin is a system of two independent vessels in one compact housing for comparative experiments and two-stage Scale-in-One processes, when culture from the seed vessel is transferred to the main by a signal of time or process. double-walled glass with coolant circulation, single-walled glass with heating mantle and autoclaved stainless steel at pressures up to 2 bar(s). Integration of GL45/GLS80 variants, eerlift and perfusion configurations is possible.

xCUBIO single is equipped with up to 16 peristaltic pumps and up to 12 gas flow regulators (MFC); xCUBIO twin - up to 8 pumps and up to 6 MFC for each of the two vessels. The control and measurement part includes a pH electrode with recalibration, a dissolved oxygen sensor (electrochemical or optical), two temperature sensors (medium and coolant, foam and level control. Optionally available exhaust gas analysis (O2/CO2 with OUR, CER, RQ), online measurement of optical density, cell density, dissolved CO2, glucose and methanol. Dosing of gases (air, O2, N2, CO2) is performed via MFC with automatic valve logic; stirring - Rushton stirrings, Automation is built on the xCUBIO platform: sequence and valve graphics editors, temporal parameter profiles, integration with weights for gravimetric dosing, remote access over VNC, OPC communication and data export to CSV.

Key figures

250 ml - 10 l

working-room

16

peristaltic pump

12

gas regulators

Applications

Microbial fermentation
Culture of mammalian and insect cells
Anaerobic cultivation
Cultivation of Pichia/Komagataella
Educational and research objectives

Models and configurations

xCUBIO single
xCUBIO twin

Vascular configuration

Double-walled glass vessel with heat carrier circulation
Single-walled glass vessel with heating mantle
Autoclavable stainless steel vessel, pressure up to 2 bar(s)

Dosing and stirring

xCUBIO single – up to 16 pumps and up to 12 gas flow regulators (MFCs)
xCUBIO twin – up to 8 pumps and up to 6 MFCs for each of the two vessels
Rushton mixers, three-blade segment or blade design

Automation of xCUBIO

Graphic editors of sequences and valve logic
Temporary parameter profiles, integration with weights for gravimetric dosing
Remote access over VNC, OPC communication, data export to CSV

Working volume and vessel

Workload	250 ml - 10 l
Vessel material	glass (one-/double-walled) or autoclaved stainless steel
Pressure (steel vessel)	up to 2 bar(s)

Pumps and gas dosing

Pumps.	to 16 (single) up to 8 per vessel (twin)
Gas flow regulators (MFC)	to 12 (single) up to 6 per vessel (twin)
Metered gases	air, O2, N2, CO2

Instrumentation and measurement

pH	calibrated
Dissolved oxygen	electrochemical
Temperature	two sensors - medium and heat carrier
Foam/level	sensors with adjustable immersion length

Measurement and sampling options

Analysis of exhaust gas O2/CO2

Calculation OUR, CER, RQ

Online optical density/biomass sensor

Monitoring of culture growth without sampling

Automatic bioprobe sampling system

scheduling

Related equipment types

Bioreactors and fermenters
Sampling systems for bioreactors
Vessels for bioreactors
Bioprocess automation systems

Classification

Biotechnology and bioprocesses
Bioreactors and fermenters
Microbiological equipment
Cultivation
Shaker incubators and small-volume bioreactors
Desktop bioreactors xCUBIO single / xCUBIO twin